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KMID : 0383820130740050235
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Tuberculosis and Respiratory Diseases
2013 Volume.74 No. 5 p.235 ~ p.239
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Fatal Interstitial Pneumonitis Rapidly Developed after the First Cycle of CHOP with Etoposide Combination Chemotherapy in a Patient with Lymphoma
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Park Hyung-Chul
Ahn Jae-Sook
Yang Deok-Hwan
Jung Sung-Hoon
Oh In-Jae
Choi Song
Lee Seung-Shin
Kim Mi-Young
Kim Yeo-Kyeoung
Kim Hyeoung-Joon
Lee Je-Jung
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Abstract
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Several chemotherapeutic agents are known to develop pulmonary toxicities in cancer patients, although the frequency of incidence varies. Cyclophosphamide is a commonly encountered agent that is toxic to the lung. Additionally, granulocyte colony-stimulating factor (G-CSF) being used for the recovery from neutropenia can exacerbate lung injury. However, most of the patients reported previously that the drug-induced interstitial pneumonitis were developed after three to four cycles of chemotherapy. Hereby, we report a case of peripheral T cell lymphoma which rapidly developed a fatal interstitial pneumonitis after the first cycle of combined chemotherapy with cyclophosphamide, adriamycin, vincristine, prednisolone, and etoposide and the patient had also treated with G-CSF during neutropenic period.
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KEYWORD
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Lymphoma, Lung Diseases, Interstitial, Granulocyte Colony-Stimulating Factor, Drug Therapy
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